Explores the basic concepts of medicinal chemistry. An understanding of structure and stereochemistry and of chirality and drug design is developed. Drug activity is discussed in general terms of structure-activity relationships such as observed in the interaction of enzymes with substrates and inhibitors, and receptors with agonists and antagonists. Selective drugs and their mode of action include sulfa drugs, B-lactam antibiotics, agents to control Parkinson?s disease and anticancer drugs. PREREQ: CHMI 2427 and 2227. (lec 3) cr 3